Reconstructing Breakage Fusion Bridge Architectures Using Noisy Copy Numbers
نویسندگان
چکیده
منابع مشابه
Combinatorics of the Breakage-Fusion-Bridge Mechanism
The breakage-fusion-bridge (BFB) mechanism was proposed over seven decades ago and is a source of genomic variability and gene amplification in cancer. Here we formally model and analyze the BFB mechanism, to our knowledge the first time this has been undertaken. We show that BFB can be modeled as successive inverted prefix duplications of a string. Using this model, we show that BFB can achiev...
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It has long been known that rearrangements of chromosomes through breakage-fusion-bridge (BFB) cycles may cause variability of phenotypic and genetic traits within a cell population. Because intercellular heterogeneity is often found in neoplastic tissues, we investigated the occurrence of BFB events in human solid tumors. Evidence of frequent BFB events was found in malignancies that showed un...
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During the development of disomic additions of rye (Secale cereak L.) chromosomes to wheat (Triticum aestivum L.), two reverse tandem duplications on wheat chromosomes 3D and 4A were isolated. By virtue of their meiotic pairing, the reverse tandem duplications initiated the chromatid type of the breakagefusion-bridge (BFB) cycle. This BFB cycle continued through pollen mitoses and in the early ...
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ژورنال
عنوان ژورنال: Journal of Computational Biology
سال: 2015
ISSN: 1066-5277,1557-8666
DOI: 10.1089/cmb.2014.0166